Constitution
Constitution measures toughness, endurance, and the ability to keep functioning under punishment. It is rarely flashy, but it is one of the most universally useful scores because nearly every character values staying conscious, resisting attrition, and enduring sustained pressure.
Hit points. Constitution is the score most players feel first because it directly shapes how much punishment a character can absorb before the fight becomes desperate.
Endurance under pressure. Hazards, forced marches, poison, sickness, and all sorts of extended stress often care whether the character can keep going after the first clean plan collapses.
Spellcasting stability. Casters may not lead with Constitution, but they often regret neglecting it when fights become long, messy, and hostile to concentration or simple survival.
Treat it as a floor score
Even if Constitution is not one of your headline stats, it is usually worth keeping high enough that the character survives routine attrition.
Front-liners should respect it
Any character expected to stand where enemies can actually reach them should think hard before making Constitution an afterthought.